Formulation and Evaluation of Novel Bilayer Floating and Sustained Release Drug Delivery System of Diltiazem HCl
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چکیده
منابع مشابه
Formulation Development and Evaluation of Gastro Retentive Floating Drug Delivery System for Novel Fluoroquinolone using Natural and Semisynthetic Polymers
The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various release retardants. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Floating tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK4M, HPMCK15M and HPMCK100M with effervescent mixtures by direct compression technique. Totally 9 formulations were...
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The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...
متن کاملFormulation development and evaluation of Diltiazem HCl sustained release matrix tablets using HPMC K4M and K100M.
The aim of this study was to develop a sustained release hydrophilic matrix tablet of Diltiazem HCl and evaluates the effect of formulation variables (e.g. lubricant, binder, polymer content and viscosity grades of HPMC) on drug release. Twelve different formulations (F1-F12) were prepared by direct compression. The results of the physical parameters and assay were found to be within the accept...
متن کاملFormulation and Evaluation of Floating Gastroretentive Drug Delivery System of Diltiazem Hydrochloride
The present investigation describes the design and evaluation of monolithic gastro retentive dosage forms of diltiazem. Hydrophilic cellulose derivatives, Sodium alginate, Sodium carboxy methyl cellulose, Polyox, Methocel K100M in combination with Methocel E6LV are used as the rate controlling polymers. Sodium bicarbonate was incorporated as gas generating agent. Tablets were prepared by employ...
متن کاملSolid Sirolimus Self-microemulsifying Drug Delivery System: Development and Evaluation of Tablets with Sustained Release Property
The clinical application of sirolimus (SRL) as an immunosuppressive agent is largely hampered by its narrow therapeutic range. This study focused on developing SRL tablets with a sustained release profile for better safety. SRL was highly water insoluble and its solubility has been efficiently enhanced by preparing self-microemulsifying drug delivery system (SMEDDS). The SRL-SMEDDS was physical...
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ژورنال
عنوان ژورنال: International Journal of Drug Development and Research
سال: 2019
ISSN: 0975-9344
DOI: 10.21767/0975-9344.1000127